'Love & Other Drugs:' Are Anne & Jake the Hottest Repeat Co-Stars?

Jake Gyllenhaal and Anne Hathaway are hot for each other in the brand-new romantic comedy, Love and Other Drugs, which opens November 24.

If you're having a feeling of deja vu seeing the two together, that's because they've starred together before -- as a married couple in Brokeback Mountain (although their characters weren't so hot for each other that time around).

Obviously, Anne and Jake are far from being the first actors to co-star together more than once. Here are a few of our favorite hottest repeat celebrity co-stars.

Leonardo DiCaprio and Kate Winslet first broke our hearts in Titanic (1997) and then did it all over again in Revolutionary Road (2008).

Tom Cruise and Cameron Diaz are no strangers to sharing a movie billing more than once -- first in Vanilla Sky (2001) and later in this year's Knight and Day.

Brad Pitt and Cate Blanchett showed us how intense they can together in Babel (2006) and The Curious Case of Benjamin Button (2008).

Julia Roberts was Richard Gere's pretty woman not once but twice -- first in Pretty Woman (1990) and then in Runaway Bride (1999).

Another leading lady who is a good match for Mr. Gere? The gorgeous Diane Lane. The two co-starred in The Cotton Club (1984), Unfaithful (2002), and Nights in Rodanthe (2008).

Finally, as we saw in Sleepless in Seattle (1993), Joe Versus the Volcano (1990), and You Got Mail (1998), Tom Hanks and Meg Ryan are the classic Hollywood pair.

Who are your favorite repeat celebrity co-stars?

Image via 20th Century Fox