16 Movie Stars Who Are Best Friends On & Off the Big Screen (PHOTOS)

Michele Marin | Jul 22, 2015 Celebrities
16 Movie Stars Who Are Best Friends On & Off the Big Screen (PHOTOS)

From Hollywood to the Hamptons, these "reel" besties not only share the silver screen, they also share scripts, secrets, and sunscreen! Some of these iconic pairs have known each other since they were mere wee ones, while others bonded over screenplays. The lucky few get to show up on set with their BFF on a regular basis. 

When you get to laugh, cry and rehearse together, it makes for some good bonding time, and surely some great takes. Check out these famous celebs who are besties both on and off screen!


Image @ Reuters/Corbis

  • Cameron Diaz & Drew Barrymore


    Image © Reuters/Corbis

    Baby showers, weddings — who else would you expect to take part in these major life events if not your BFF? It's not just milestones that bond Cameron Diaz and Drew Barrymore. These "Charlie's Angels" have been spotted sweating it out at L.A. dance classes and enjoying girls' nights in West Hollywood. 

  • Sofia Vergara & Reese Witherspoon


    Iimage © Splash News/Corbis

    These two bombshells became fast friends while filming their comedy, Hot Pursuit. Sofia Vegara and Reese Witherspoon candidly joke about each other's eating habits and lavish each other with praise for their talents. Seems like "happily ever after" is definitely in this duo's future.

  • Tina Fey & Amy Poehler


    Image © MarioAnzuoni/Reuters/Corbis

    These SNL alumsn have starred in films such as Baby Mama and hosted the Emmys together multiple times. Now funny ladies Tina Fey and Amy Poehler are set to pair up again for a new comedy called Sisters in late 2015. 

  • Ashley Tisdale & Vanessa Hudgens


    Image © Mike Nelson/epa/Corbis

    They may have competed for Troy Bolton's affections in High School Musical, but the real-life pals are so close, Hudgens was a bridesmaid in Ashley Tisdale's wedding. She also sang her pal's praises on her 30th birthday with a heartfelt tweet.  

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  • Kate Hudson & Liv Tyler


    Image © Fairchild Photo Service/Conde Nast/Corbis

    Both children of famous parents, Liv Tyler and Kate Hudson attended Crossroads School For Arts and Science in the 1990s, where they became close. Later they starred in the film Dr. T and the Women, and have remained tight ever since.

  • Salma Hayek & Penelope Cruz


    Image © Fernando Allende/Splash News

    It was Salma Hayek who reportedly picked up Penelope Cruz from the airport when she first came to the U.S. to film a movie. Taking her under her wing, Salma was quick to show her friend around Tinsletown. You can catch these beauties playing badass bankrobbers in the film Bandidas, but you're more likey to spy them having dinner or cheering each other on at the Oscars.

  • George Clooney & Brad Pitt


    Image © Hubert Boesl/Corbis

    Everyone loves a good joke. Maybe that's why Brad Pitt and George Clooney get along so well both on and off movie sets. Often playing practical jokes on each other during the filming of Ocean's 11 as well as its sequels, they've continued the fun off-screen for years.

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  • Leonardo DiCaprio & Tobey Maguire


    Image © 2009Game Piks Photo/ Corbis

    These two have been friends for over 20 years, and in Hollywood, that's a lifetime! Leonardo DiCaprio and Tobey Maguire met while on an audition for the same role in the 1980s and have been friends since. They went on to star together in The Great Gatsby and This Boy's Life. You can often spot them on the Jumbotron at a Lakers game.

  • Maya Rudolph & Kristen Wiig


    Image © Derek Storm/Splash News/Corbis


    Maya Rudolph and Kristen Wiig met while performing at The Groundlings Theatre and School in L.A., and went on to star in Saturday Night Live and the 2011 film Friends with Kids. But it was their hysterical film Bridesmaids that proved these two ladies have the chops to go the distance both on and off screen. 

  • Naomi Watts & Nicole Kidman


    Image © Fernando Allende/Splash News

    Longtime friends Naomi Watts and Nicole Kidman shared a kiss at the 2015 Women in Film Crystal + Lucy Awards. Perhaps that's because if you meet your bestie while auditioning for a bikini ad and you're still going strong 20 years later, you seal it with a smooch!

  • Ryan Reynolds & Sandra Bullock


    Image © FrankTrapper/Corbis

    Who was there offering support for Bullock during her divorce? None other than her pal, Ryan Reynolds. In fact Reynolds reportedly has also been a great buddy to Sandra Bullock's son, Louis. Their blossoming friendship was no doubt a bonus when they co-starred in 2009's The Proposal. Maybe that's why Reynolds has said that working with Bullock is like working with family.

  • Bradley Cooper & Justin Bartha


    Image © Fairchild Photo Service/Conde Nast/Corbis

    Failure to Launch introduced them, but it was The Hangover that sealed this bestie deal. They're so close that Justin Bartha jokingly asked journalist Jill Martin to stop texting him about Cooper during an on-camera interview. Who can blame her? He's hot!

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  • Anne Hathaway & Hugh Jackman


    Image © James Higgins/ Corbis

    Both Jackman and Hathaway were nominated for their roles in 2012's Les Miserables, but they actually met while hosting the Oscars in 2011, where she dedicated a song to him. It's no secret that there's an enormous amount of mutual admiration between this pair.

  • Seth Rogen & James Franco


    Image © Kevork Jansezian/Reuters/Corbis

    If you really want a good laugh, check out Seth Rogen and James Franco's Rolling Stone cover of John Lennon and Yoko Ono, which they recently posted on Instagram. Apparently the zany pals had enough downtime on the set of their last movie, The Interview, to also make a spoof of Kayne West's video for "Bound 2," which they appropriately titled, "Bound 3."

  • Cara Delevingne & Nat Wolff


    Image © James Higgins/Corbis

    If you aren't already excited to see Paper Towns, maybe seeing these two besties in matching outfits may spark some enthusiasm. Cara Delevingne says Nat Wolff just makes her job "easy." Now that's a good reason to show up for work!

  • Matt Damon & Ben Affleck


    Image © Jared Milgrim/ Corbis

    Don't all best friends write their first screenplays together, launch production companies, and star in the same movies? Well, maybe the lucky ones. Friends since childhood, Ben Affleck and Matt Damon grew up together in Cambridge and have gone on to co-star in over 10 films. They also do a few low-key things together, too, like take family vacations with their broods. 

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